Carbomer as a sustained release agent in chemical drugs CAS NO.9003-01-4

1. High daily output and fast delivery

Desheng has a professional production base and adopts imported production equipment. The daily output of Carbomer 980 can reach 3-5 tons, which can meet the needs of customers for large quantities of orders. Customers no longer have to worry about the delivery cycle.

2. Customized parameters

Desun Carbomer 980 needs better thickening performance and high viscosity, viscosity can be customized according to customer needs

3. Good after-sales service

Desheng provides good after-sales service and guarantees that if there is any quality problem, it will result in a return. If there are no special circumstances, all product shipping costs will be borne by the company.

4. High cost performance

Desheng is carrying out the annual ultimate discount event. Carbomer has a preferential price of 130 yuan/kg over 980 tons. The product quality is guaranteed. Free trial installation is available.

carbomer , also known as carboper, is a polymer polyacrylic acid cross-linked polymer. It is usually used as thickener, gel and emulsifier in daily chemicals. It can also be used as pharmaceutical excipients as skeleton materials, and has the role of slow release agent or adhesive and dispersant. It has broad prospects in many fields.

Carbomer is used as a sustained-release agent of chemical drugs

Carbomer is widely used as a chemical sustained-release agent, including oral and external use. It is in the stage of rapid development and research in China. In this paper, a kind of toxin carbomer gel is used to illustrate the application characteristics, drug release mechanism, preparation process, release factors and practical application of carbomer sustained release gel. Toxoid, i.e. force reducing toxin and denatured toxin, refers to some toxins that lose their original toxicity and still retain their immunogenicity after denaturation or chemical modification. After detoxification, the toxoid toxicity disappears, and it can still stimulate the human body to produce antitoxin and play an immune role.

Sustained release agent of carbomer for tetanus toxoid

Bacterial exotoxin is treated with 0.3% ~ 0.4% formaldehyde to remove its toxicity and can be made into toxoid. Tetanus (Clostridium tetanus) toxoid is one of them. Study on its release in carbomer (flocculent precipitation method): dissolve 25lf / ml tetanus toxoid in phosphoric acid buffer and distilled water respectively, then add the same amount of Carbopol with three concentrations of 0.25%, 0.125% and 0.625%, fully mix, separate Carbopol with NaCl precipitation method, and then take the supernatant and Carbopol precipitation for flocculent reaction respectively.

The results showed that the content of tetanus toxoid in the supernatant was very high and showed typical flocculent precipitation, while the Carbopol precipitation did not contain any tetanus toxoid, and the flocculent reaction was negative. This study preliminarily established the biological detection method of the product in carboper gel and the conditions for its dissolution in carboper. It was determined that the concentration of Carbopol in this release study should not be higher than 0.25%.

In addition, many other drugs use carbomer as skeleton material or carrier. The drugs are evenly dispersed in carbomer gel, and will not be dissolved directly in solution (blood or body fluid), but slowly release, so as to achieve better efficacy. Desheng is a manufacturer of Carbomer, which can provide a variety of models and required carbomer raw materials.