Carbomer as a sustained release agent in chemical medicine CAS NO.9003-01-4

1. High daily output and fast delivery

Desheng has a professional production base and adopts imported production equipment. The daily output of Carbomer 980 can reach 3-5 tons, which can meet the needs of customers for large quantities of orders. Customers no longer have to worry about the delivery cycle.

2. Customized parameters

Desun Carbomer 980 needs better thickening performance and high viscosity, viscosity can be customized according to customer needs

3. Good after-sales service

Desheng provides good after-sales service and guarantees that if there is any quality problem, it will result in a return. If there are no special circumstances, all product shipping costs will be borne by the company.

4. High cost performance

Desheng is carrying out the annual ultimate discount event. Carbomer has a preferential price of 130 yuan/kg over 980 tons. The product quality is guaranteed. Free trial installation is available.

 Carbomer  also known as Carbopol, is a high molecular polyacrylic acid cross-linked polymer, usually used as a thickener, gelling agent, emulsifier in daily chemical products, and can also be used as a skeleton material in pharmaceutical excipients , has the function of slow release agent or adhesive and dispersant, and has broad prospects in many fields.
Carbomer is used as a chemical drug release agent
Carbomer as a chemical sustained-release agent has many applications, including oral and external use, and is in the stage of rapid development and research in my country. Here, a toxoid carbomer gel is used as an example to illustrate the application characteristics, drug release mechanism, preparation process, factors affecting drug release and practical application of carbomer sustained-release preparations. Toxoids, namely force-reducing toxins and denatured toxins, refer to some toxins that have been denatured or chemically modified to lose their original toxicity but still retain their immunogenicity. The toxicity of the toxoid after detoxification disappears, but it can still stimulate the human body to produce antitoxin and play an immune role.
Sustained-release formulation of carbomer for tetanus toxoid
Bacterial exotoxin is treated with 0.3%~0.4% formaldehyde to remove its toxicity and can be made into toxoid. Tetanus (Clostridium tetani) toxoid is one of them. Its release study in carbomer (using flocculation precipitation method): Dissolve 25Lf/mL tetanus toxoid in phosphate buffer and distilled water, respectively, and then add equal amounts of 0.25%, 0.125%, and 0.625% Concentration of Carbopol, mix well, separate Carbopol by NaCl precipitation, and then take the supernatant and Carbopol precipitate for flocculation reaction respectively.
The results of the study found that the content of tetanus toxoid in the supernatant was very high, showing a typical flocculent precipitate, while the Carbopol precipitate did not contain any tetanus toxoid, and the flocculent reaction was negative. This study preliminarily established the biological detection method of this product in carbopol gel and the conditions for its dissolution in carbopol. Carbopol concentrations determined for this release study should not be higher than 0.25%.
In addition, there are many other medicines that use carbomer as a skeleton material or carrier. The medicine is uniformly dispersed in the carbomer gel, and will not dissolve directly in the solution (blood, body fluid), but is slowly released, which can play a better role. medicinal effect. Desheng is a carbomer manufacturer, which can provide various types and requirements of carbomer raw materials.