Differences between heparin anticoagulants and other anticoagulants CAS NO.9045-22-1

1. Factory production, preferential price, and spot supply of conventional products;

2. Support customization of serum separator, such as special customization of specific gravity and viscosity;

3. Desheng is a manufacturer specializing in the production of a full range of vascular additives, with a wide range of products, which can provide you with more comprehensive services;

4. Desheng has been engaged in blood vessel collection industry for 14 years. Our products are independently developed and produced. We have the ability to solve most of the problems in vascular collection and provide customers with safer services.

5. Desheng began to engage in foreign trade in 2010. We have our own export rights.

The heparin anticoagulant mentioned here mainly refers to heparin sodium or heparin lithium used for anticoagulation of blood in vitro, rather than heparin drugs. In addition to heparin, there are potassium EDTA, sodium citrate, potassium oxalate and other anticoagulants in vitro. Heparin anticoagulants are very different from these.

Firstly, heparin is a natural anticoagulant component, which is found and named from animal liver. It is usually extracted from sheep's small intestine or pig's small intestine, and the content is very small. It belongs to a mucopolysaccharide sulfate. Most animals have a natural anticoagulant substance, which has unique properties compared with other anticoagulants. Potassium EDTA, sodium citrate or potassium oxalate anticoagulants can be directly synthesized or extracted from plants. They have a wide range of sources and low raw material cost. The differences of different products are mainly reflected in the purification process and technology.

Heparin anticoagulant

Price of heparin anticoagulant

An obvious difference between heparin anticoagulants and other types of anticoagulants is the price. For example, the price of EDTA anticoagulants is usually 200-400 yuan per kilogram, while the price of heparin is hundreds of yuan per gram. This is because the cost of heparin is different from other anticoagulants. It needs to be extracted from animals. Extracting a kilogram of heparin requires thousands of pigs.

Dosage of heparin in blood collection vessels

The amount of heparin in the blood collection vessel is related to the blood collection volume. Calculated according to the 5ml blood collection volume of a branch pipe, 100iu titer unit of heparin is required, with a weight of about 0.7mg; In the case of EDTA dipotassium anticoagulant, 9-10 mg is required. It can also be seen from here that the anticoagulant efficiency of heparin is very high.

Characteristics of heparin anticoagulant

Heparin is a physiological anticoagulant, which has the function of antithrombin, inhibits the activation of coagulation factors V, VIII and Xi, and promotes fibrinolysis. Heparin anticoagulants affect blood cell volume and rarely produce hemolysis. They are commonly used in blood cell volume, blood pH, blood gas analysis and other biochemical determinations. They are also suitable for red cell osmotic fragility test. Heparin anticoagulant is not suitable for blood smear examination, because it will appear blue background during Wright's staining, and it is not suitable for the examination of coagulation factors.

Desheng must remind you that the anticoagulant effect of heparin is not irreversible, that is, the blood samples anticoagulated with heparin will still coagulate after a long time, so the test needs to be carried out immediately. In addition to heparin sodium, Desheng also independently produces heparin lithium, with more than ten years of rich experience.