The role and application of biological buffer PEP CAS NO.35556-70-8

1. Factory production, more favorable prices, and regular products are available in stock;

2. Desheng is a manufacturer of a series of biological buffer products. At present, there are many kinds of products, which can provide you with more comprehensive services;

3. Desheng has been in this industry for 16 years. Our products are independently developed and manufactured. Biological buffer has high purity and guaranteed product quality.

4. Desheng began to engage in foreign trade in 2010. We have our own right to export.

Phosphoenolpyruvate (PEP)  is a functional carbohydrate metabolite with cytoprotective and antioxidant activities and has potential as a therapeutic agent for diseases involving oxidative stress. But it did not show any effect at low doses (0.1, 1 mM). PEP (0.1-10 mM) also attenuated cellular damage but did not attenuate the decrease in intracellular ATP content induced by the glycolysis inhibitor 2-deoxy-D-glucose.

PEP also attenuated organ preservation, histological changes and changes in oxidative stress parameters (measured by thiobarbituric acid-reactive substances and glutathione content) induced by liver preservation for 72 h of aminotransferase and lactate dehydrogenase Elevated leakage. Its effects are comparable to UW solution, a gold standard organ preservation agent. PEP treatment attenuated the decrease in ATP content in the liver during cold storage. PEP prevented cellular damage and increased intracellular reactive oxygen species in HepG2 cells. Furthermore, PEP scavenged hydroxyl radicals but had no effect on superoxide anion, as assessed by electron paramagnetic resonance spin trapping.

Desheng Company is a professional manufacturer of biological buffers. The product quality and customer service of the biological buffer PEP currently produced have been recognized by many customers, and it has been designated as a long-term supplier.