Solving common problems in the application of serum separation gel CAS NO.000-00-0

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In biochemical tests, it is often seen that after centrifugation of the blood collection tube with separating gel, the serum in the upper layer is red, which is the rupture of blood cells in the test tube and the escape of hemoglobin. Outside the human body, if the red blood cells are in a solution with too low osmotic pressure, water enters the red blood cells, causing swelling and rupture, resulting in hemolysis. Hemolysis in humans, mainly due to intrinsic defects in red blood cells, or due to plasma
There are autoantibodies, chemicals, snake venom and other factors in the body, which cause excessive destruction of red blood cells.
So why does hemolysis occur in a test tube containing  serum separation gel
First, let's understand the principle of separating serum and blood clot with separating gel. After the blood sample is put into the test tube, under the action of thrombin factor, fibrinogen is converted into insoluble fibrin filaments, and the blood cells are surrounded to form blood clots, which naturally coagulate, and a part of serum is precipitated, but it is difficult to fully coagulate. After adding the separating gel, due to the thixotropic nature of the separating gel, it becomes liquid and flows in the test tube under the action of centrifugal force. Due to the specific gravity, the blood clot with higher specific gravity settles at the bottom, the small serum is on the top, and the separating gel is in the middle. After the centrifugal force disappears, the separating gel becomes gel-like and completely separates the blood clot from the serum. Separating gel is inert, it does not react with anything in the chemical reaction. So it does not change the products of the reaction, nor does it destroy the hemoglobin in the cells. From this point of view, serum separation gel is not the cause of the destruction of blood cells.
So what are the other factors that cause blood cell damage
1. Disinfect with iodine, the alcohol in the iodine is not dry and enters the blood collection tube to cause pollution and destroy red blood cells;
2. Blood collection, if the blood collection volume is insufficient and the negative pressure is too large, the red blood cells in the tube will rupture, which will cause hemolysis;
3. Transfer the blood sample to the blood collection tube with a blood collection needle, and damage the blood cells due to the action of pressure;
4. Invert and mix the blood collection tube about 5 times. If the force is too large, the blood cells will rupture;
5. Let stand for 30 minutes to allow the blood to coagulate naturally. Centrifuge the blood before it has fully reached the time of coagulation;
Hubei Xindesheng Materials Co., Ltd. specializes in the production of anti-irradiation serum separation gel, with stable delivery and guaranteed quality. Welcome to consult.