Application of Bicine in In Vitro Diagnosis and Other Aspects CAS NO.150-25-4

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Bicine (N,N-Dihydroxyethylglycine, CAS: 150-25-4) is a white powder, which is widely used as an organic compound as a buffer. Bicine is a zwitterionic biological buffer commonly used as a buffer in biological and biochemical research. It is one of Good's buffers with a pKa of 8.35 at 20°C. It is prepared by reacting glycine with ethylene oxide and then hydrolyzing the resulting lactone. Bicine can be used for gas desulfurization of contaminants in amine systems. It is formed by amine degradation in the presence of O2, SO2, H2S or thiosulfate.
one. Bicine as Good's Buffer is usually used in protein crystallization solutions. Bicine is a very widely used Buffer. It is used in enzyme reaction buffer, electrophoresis buffer, and the working concentration is from
3-100mM. For biological buffers, especially for low-temperature biochemical research; for the preparation of stable substrate solutions for the determination of serum guaninease; spacer arm in the fractionation of plasma proteins by isotachophoresis using cross-linked dextran.
two. Bicine has been used as a buffer in chromatography and polymerase chain reaction
Bicine is an amphoteric amino acid buffer that is active in the pH 7.6-9.0 range (pKa 8.3 at 25°C). It is the recommended buffer for low temperature biochemical reactions. And it has the advantages of not participating in and not interfering with the biochemical reaction process, and being resistant to chemical action and enzymatic hydrolysis, so it is often used as a buffer in chromatography and polymerase chain reaction.
three. Mobile Phase Buffers and Eluents for Bicine in Cation Exchange Chromatography
The use of Bicine in thin layer ion exchange for protein resolution chromatography methods has been demonstrated. Bicine has been used for peptide and protein crystallization. The quaternary transition state analog creatine kinase used Bicine in the reaction buffer. A heterogeneous buffer system for protein SDS-PAGE combined with Bicine-bound peptides has been widely used in in vitro diagnostic clinical trials.
Four. Used as a chelating agent for soil remediation.
Because Bicine molecule contains two -OH and one -COOH, it has good chelating properties and can chelate heavy metal ions such as copper, cadmium, and lead ions, but cannot chelate calcium and magnesium ions. Therefore, Bicine is often used as a chelating agent to remediate heavy metal-contaminated soils. Bicine|150-25-4| has good elution ability for heavy metals under neutral and acidic conditions, and can efficiently remove Cu, Cd and Pb ions in polluted soil. Bicine|150-25-4| is The active ingredient eluent can not only wash and repair heavy metal polluted soil, but also avoid the loss of calcium and magnesium of plant nutrients in the soil, which is safe and environmentally friendly, and will not cause secondary pollution to the environment.
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